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CDK4 PROTEIN KINASE
Descriptors Found:
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DeCS
Descriptor
English
:
Cyclin-Dependent Kinase 4
Descriptor
Spanish
:
Quinasa 4 Dependiente de la Ciclina
Descriptor
Portuguese
:
Quinase 4 Dependente de Ciclina
Synonyms
English
:
Cdk4 Protein Kinase
Tree Number:
D08.811.913.696.620.682.700.646.500.875
D12.644.360.250.451
D12.776.167.200.451
D12.776.476.250.451
Definition
English
:
Cyclin-dependent kinase 4
is a key regulator of
G1 PHASE
of the
CELL CYCLE
. It partners with
CYCLIN D
to phosphorylate
RETINOBLASTOMA PROTEIN
. CDK4 activity is inhibited by
CYCLIN-DEPENDENT KINASE INHIBITOR P16.
History Note
English
:
2006(1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50715
Unique Identifier:
D051358
Occurrence in VHL
:
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